| Named By: | Dollo in 1889 |
| Time Period: | Late Cretaceous |
| Location: | Fossil locations suggest a worldwide distribution, but especially well known from Europe and North America |
| Size: | Depending upon the species, Prognathodon could range between 6 to possibly just under 14 meters in length |
| Diet: | Carnivore |
| Fossil(s): | Many specimens. Usually just skulls and skull material, more complete remains are known, especially two specimens from Canada. Stomach contents have also been found |
| Classification: | | Chordata | Reptilia | Squamata | Scleroglossa | Mosasauridae | Mosasaurinae | |
| Also known as: | | Ancylocentrum hungerfordi | Oronosaurus | |
Prognathodon ('forejaw tooth') is an extinct genus of mosasaur squamate reptile.